Early enteral nutrition's impact on the postoperative nutritional state and the blood immunological index values in patients undergoing radical gastric cancer surgery

Abstract

Abstract
Background: Early Enteral Nutrition (EEN) is the most commonly used postoperative feeding method. It is more in accordance with the physiological state in order to provide complete nutrition with less complications, making it a safe and effective technique of efficiently improving visceral function. EEN is more convenient for blood glucose regulation because, on the one hand, it maintains intestinal mucosal integrity and enhances intestinal permeability, allowing glucose-dependent insulinotropic hormones to be secreted. The influence of early enteral EEN on nutrient intake and blood glucose levels in patients with stomach cancer accompanied by diabetes mellitus.
Objective: The objective of this research was to investigate the impact of early enteral nutrition on the postoperative nutritional status and blood immunological index values in patients with radical gastric cancer surgery.
Methods: In this experiment, a total of 130 patients were included in this study who underwent radical resection of gastric cancer during October 2019 to October 2020. Using the random number table method, they were divided into control group and test group. This was done to investigate the effect of early enteral nutrition on postoperative nourishing state and blood immune index levels in patients undergoing radical gastric cancer surgery, the test group received enteral nutrition emulsion TPF after surgery, while the control group received total parenteral nutrition support 24 hours following surgery.
Results: The time for patients in the test group to return to normal anus and defecation, total naso-intestinal tube drainage, and naso-intestinal tube placement were significantly reduced when compared to the control group; on the first day after surgery, Hb, Alb, PA, and surgery in the 2 groups were considerably distinct. It reduced dramatically as compared to the test group, and there was no notable change between the observation and control groups. On the 8th day of surgery, the Hb, Alb, and PA indicators in the treated groups were significantly increased as compared to the control group; on the 1st day after surgery, IgA, IgM, IgG, CD3+, CD4+, CD4+/CD8+ were considerably lower in the tested groups as compared to before surgery; on the 8th day after the surgery all the participants in the test group exceeded the levels of the control group.
Conclusion: EEN can successfully increase intestinal function restoration in patients with radical gastric cancer surgery, by improving clinical efficacy and immunological function, through the improvement of the patients' nutritional condition after surgery, and by preventing the incidence of problems. [Ethiop. J. Health Dev. 2022; 36(3) 00-00]
Keywords: early enteral nutrition; radical gastric cancer; nutritional status; immune indicators